Publications

Discover more from Beactica Therapeutics' world-class R&D team.

2025

Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point

FitzGerald EA, Rachman MA, Cederfelt D, Myers NEM, Kovryzchenko D, Zhang H, Barril X, Koehler K, Danielson...

2024

Degraders of TEAD Transcription Factors Based on Interface 3 Binders

Sawant R, Geitmann M, Gossas T, Emond WB, Bremberg U, Koehler K, Ceribelli M, Thomas CJ & Brandt P. Proceedings...

2023

Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors

FitzGerald EA, Vagrys D, Opassi G, Klein HF, Hamilton DJ, Talibov VO, Abramsson M, Moberg A, Lindgren...

2023

Potentiation of Immunotherapy by LSD1 Modulation

Emond WB, Sawant R, Geitmann M, Winquist J, Brandt P, Bremberg U, Källblad P, Parrow V, Andersson C,...

2021

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase

Talibov VO, Fabini E, FitzGerald EA, Tedesco D, Cederfeldt D, Talu MJ, Rachman MM, Mihalic F, Manoni...

2021

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

FitzGerald EA, Butko MT, Boronat P, Cederfelt D, Abramsson M, Ludviksdottir H, van Muijlwijk-Koezen JE,...

2019

Comparison of metabolic and mitogenic response in vitro of the rapid-acting insulin lispro product SAR342434, and US- and EU-approved Humalog®

Korn M, Wohlfart P, Gossas T, Kullman-Magnusson M, Niederhaus B, Dedio J, Tennagels N. (2019) Regul Toxicol...

2019

LSD1 modulation by allosteric ligands

Emond WB, Geitmann M, Jarvius M, Koehler K, Källblad P, Niklasson M, Parrow V, Sawant R, Sjöberg M, Winquist...

2018

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Pandya NJ, Seeger C, Babai N, Gonzalez-Lozano MA, Mack V, Lodder JC, Gouwenberg Y, Mansvelder HD, Danielson...

2017

Development of (4-cyanophenyl)glycine derivatives as reversible inhibitors of lysine specific demethylase 1

Mould DP, Alli C, Bremberg U, Cartic S, Jordan AM, Geitmann M, Maiques-Diaz A, McGonagle AE, Somervaille...

2017

Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1

Mould DP, Bremberg U, Jordan AM, Geitmann M, McGonagle AE, Somervaille TCP, Spencer GJ, Ogilvie DJ. (2017)...

2017

Measuring the kinetic interaction of insulin analogs with solubilized full-length insulin receptors

Wohlfart P, Gossas T, Lindgren M, Kullman-Magnusson M, and Tennagels N (2017) Poster at International...

Integrated computational and biosensor-based strategies for the discovery of allosteric SMYD3 ligands using diperodon as a starting point

Degraders of TEAD Transcription Factors Based on Interface 3 Binders

Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors

Potentiation of Immunotherapy by LSD1 Modulation

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

Comparison of metabolic and mitogenic response in vitro of the rapid-acting insulin lispro product SAR342434, and US- and EU-approved Humalog®

LSD1 modulation by allosteric ligands

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Development of (4-cyanophenyl)glycine derivatives as reversible inhibitors of lysine specific demethylase 1

Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1

Measuring the kinetic interaction of insulin analogs with solubilized full-length insulin receptors

Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1

Biophysics in drug discovery: impact, challenges and opportunities

Identification and Characterization of an Irreversible Inhibitor of CDK2

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the nicotinic acetylcholine receptor

Identification of Structural-Kinetic and Structural-Thermodynamic Relationships for Thrombin Inhibitors

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors – characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Structural basis of ligand recognition in 5-HT3 receptors

Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker

Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function.

Histaminergic pharmacology of homo-oligomeric aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology

Aliskiren displays long-lasting interactions with human renin

Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: implications for the charge state of the protein ionogenic groups.

AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors

Experimental Validation of a Fragment Library for Lead Discovery using SPR Biosensor Technology

Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 Reverse transcriptase by fragment library screening

Quantification of interactions between drug leads and serum proteins by use of “binding efficiency”

Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments

A surface plasmon resonance based biosensor with full-length BACE1 in a reconstituted membrane.

Powerful protein binders from designed polypeptides and small organic molecules – a general concept for protein recognition.

Development of surface plasmon resonance biosensor assays for primary and secondary screening of AChBP ligands

Biotinylated lipid bilayer disks as model membranes for biosensor analyses

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor Ligands

Effect of protonation state of the titrable residues on the inhibitor affinity to BACE1

Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism – Importance of slow dissociation and relaxation rates for antiviral efficacy

Screening for NNRTIs with Slow Dissociation and High Affinity for a Panel of HIV-1 RT Variants

Fragment library screening and lead characterization using SPR biosensors

Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process

Structural and functional analysis of hepatitis C virus strain JFH1 polymerase

A protein interaction node at the neurotransmitter release site: Domains of Aczonin, Bassoon, CAST and Rim converge on the N-terminal domain of Munc13-1

Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis

Biomolecular Recognition of Glycosylated Peptides by GalNAc Specific Lectins

Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance

Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors

Early absorption and distribution analysis of anti-tumour and anti-AIDS drugs: Lipid membrane and plasma protein interactions

Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data

Studies of substrate-induced conformational change in human cytomegalovirus protease using optical biosensor technology

Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Kinetic and thermodynamic characterization of HIV-1 protease inhibitors

Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants

Kinetic and mechanistic analysis of the association and dissociation of inhibitors interacting with secreted aspartic acid proteases 1 and 2 from Candida albicans

Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors

Relationships between structure and interaction kinetics for HIV-1 protease inhibitors

Capture and analysis of low molecular weight ligands by surface plasmon resonance combined with mass spectrometry

Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology

Modified HIV protease inhibitors as tools in two new sensitive surface plasmon resonance biosensor screening assays

Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor based screen

Kinetic analysis of the interaction between HIV-1 protease and inhibitors using optical biosensor technology

Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology

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