Publications

Discover more from Beactica Therapeutics' world-class R&D team.

2024

Degraders of TEAD Transcription Factors Based on Interface 3 Binders

Sawant R, Geitmann M, Gossas T, Emond WB, Bremberg U, Koehler K, Ceribelli M, Thomas CJ & Brandt P. Proceedings...

2023

Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors

FitzGerald EA, Vagrys D, Opassi G, Klein HF, Hamilton DJ, Talibov VO, Abramsson M, Moberg A, Lindgren...

2023

Potentiation of Immunotherapy by LSD1 Modulation

Emond WB, Sawant R, Geitmann M, Winquist J, Brandt P, Bremberg U, Källblad P, Parrow V, Andersson C,...

2021

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase

Talibov VO, Fabini E, FitzGerald EA, Tedesco D, Cederfeldt D, Talu MJ, Rachman MM, Mihalic F, Manoni...

2021

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

FitzGerald EA, Butko MT, Boronat P, Cederfelt D, Abramsson M, Ludviksdottir H, van Muijlwijk-Koezen JE,...

2019

Comparison of metabolic and mitogenic response in vitro of the rapid-acting insulin lispro product SAR342434, and US- and EU-approved Humalog®

Korn M, Wohlfart P, Gossas T, Kullman-Magnusson M, Niederhaus B, Dedio J, Tennagels N. (2019) Regul Toxicol...

2019

LSD1 modulation by allosteric ligands

Emond WB, Geitmann M, Jarvius M, Koehler K, Källblad P, Niklasson M, Parrow V, Sawant R, Sjöberg M, Winquist...

2018

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Pandya NJ, Seeger C, Babai N, Gonzalez-Lozano MA, Mack V, Lodder JC, Gouwenberg Y, Mansvelder HD, Danielson...

2017

Development of (4-cyanophenyl)glycine derivatives as reversible inhibitors of lysine specific demethylase 1

Mould DP, Alli C, Bremberg U, Cartic S, Jordan AM, Geitmann M, Maiques-Diaz A, McGonagle AE, Somervaille...

2017

Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1

Mould DP, Bremberg U, Jordan AM, Geitmann M, McGonagle AE, Somervaille TCP, Spencer GJ, Ogilvie DJ. (2017)...

2017

Measuring the kinetic interaction of insulin analogs with solubilized full-length insulin receptors

Wohlfart P, Gossas T, Lindgren M, Kullman-Magnusson M, and Tennagels N (2017) Poster at International...

2017

Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1

Mould DP, Bremberg U, Jordan AM, Geitmann M, Maiques-Diaz A, McGonagle AE, Small HF, Somervaille TCP,...

2016

Biophysics in drug discovery: impact, challenges and opportunities

Renaud JP, Chung C-w, Danielson UH, Egner U, Hennig M, Hubbard RE & Nar H (2016) Nature Reviews Drug...

2015

Identification and Characterization of an Irreversible Inhibitor of CDK2

Anscombe E, Meschini E, Mora-Vidal R, Martin MP, Staunton D, Geitmann D, Danielson UH, Stanley WA, Wang...

2015

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the nicotinic acetylcholine receptor

Spurny R, Debaveye S, Farinha A, Veys K, Vos A.M, Gossas T, Atack J, Bertrand S, Danielson UH, Tresadern...

2013

Identification of Structural-Kinetic and Structural-Thermodynamic Relationships for Thrombin Inhibitors

Winquist J, Geschwindner S, Xue Y, Gustavsson L, Musil D, Deinum J, Danielson UH. (2013) Biochemistry,;...

2013

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors – characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Gossas T, Nordström H, Xu M-H, Sun Z-H, Lin G-Q, Wallberg H and Danielson UH (2013) Med. Chem. Commun.,...

2013

Structural basis of ligand recognition in 5-HT3 receptors

Kesters D, Thompson AJ, Brams M, van Elk R, Spurny R, Geitmann M, Villalgordo JM, Guskov A, Danielson...

2012

Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker

Solca F, Dahl G, Zoephel A, Bader G, Sanderson M, Klein C, Kraemer O, Himmelsbach F, Haaksma E, Adolf...

2012

Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function.

Seeger C, Gorny X, Reddy PP, Seidenbecher C, Danielson UH. (2012) J Mol Recognit.; 25(10):495-503.

2012

Histaminergic pharmacology of homo-oligomeric aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology

Seeger C, Christopeit T, Fuchs K, Grote K, Sieghart W, Danielson UH. (2012) Biochem Pharmacol, 84(3);341-51

2012

Aliskiren displays long-lasting interactions with human renin

Gossas T, Vrang L, Henderson I, Sedig S, Sahlberg C, Lindström E, Danielson U. H. (2012) N-S Arch. Pharmaco....

2012

Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: implications for the charge state of the protein ionogenic groups.

Domínguez JL, Gossas T, Carmen Villaverde M, Helena Danielson U, Sussman F. (2012) Biorg. Med. Chem.,...

2012

AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin

Gorny X, Mikhaylova M,Seeger C, Reddy PP, Reissner C, Schott BH, Helena Danielson U, Kreutz MR, Seidenbecher...

2011

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

Elinder, M., Geitmann, M., Gossas, T., Källblad, P., Winquist, J., Nordström, H., Hämäläinen, M. and...

2011

Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors

Geitmann, M., Dahl, G., Danielson, U.H. (2011) J. Mol. Recog. 24(1):60-70.

2011

Experimental Validation of a Fragment Library for Lead Discovery using SPR Biosensor Technology

Elinder, M., Geitmann, M., Gossas, T., Källblad, P., Winquist, J., Nordström, H., Hämäläinen, M. and...

2011

Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 Reverse transcriptase by fragment library screening

Geitmann, M., Elinder, M., Seeger, C., Brandt, P., de Esch, I. and Danielson, U.H. (2011) J. Med. Chem....

2011

Quantification of interactions between drug leads and serum proteins by use of “binding efficiency”

Svahn, S., Vrang, L., Terelius, Y., Danielson, U.H. (2011) Anal. Biochem. 409; 163–175.

2011

Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments

Brandt, P., Geitmann, M. and Danielson, U.H. (2011) J. Med. Chem. 54(3); 709-718.

2011

A surface plasmon resonance based biosensor with full-length BACE1 in a reconstituted membrane.

Christopeit, T., Stenberg, G., Gossas, T., Nyström., S., Baraznenok, V., Lindström, E., Danielson, U.H....

2011

Powerful protein binders from designed polypeptides and small organic molecules – a general concept for protein recognition.

Tegler, L.T. Nonglaton, G., Büttner, F., Caldwell, K., Christopeit, T., Danielson, U.H., Fromell, K.,...

2010

Development of surface plasmon resonance biosensor assays for primary and secondary screening of AChBP ligands

Retra, K., Geitmann, M., Kool, J., Smit, G., de Esch, I.J.P., Danielson, U.H. and Irth, H. (2010) Anal....

2010

Biotinylated lipid bilayer disks as model membranes for biosensor analyses

Lundquist, A., Hansen, S.B., Nordström, H., Danielson, U.H., Edwards, K. (2010) Anal. Biochem. 405; 153-159

2010

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor Ligands

De Kloe, G., Retra, K., Geitmann, M., Källblad, P., Nahar, T., van Elk, R., Smit, A.B., van Muijlwijk-Koezen,...

2010

Effect of protonation state of the titrable residues on the inhibitor affinity to BACE1

Domínguez, J.L., Christopeit, T., Villaverde, M.C., Gossas, T., Otero, J.M., Nyström, S., Baraznenok,...

2010

Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism – Importance of slow dissociation and relaxation rates for antiviral efficacy

Elinder, M., Selhorst, P., Vanham, G., Öberg, B., Vrang, L. and Danielson, U.H. (2010) Biochem. Pharmacol....

2009

Screening for NNRTIs with Slow Dissociation and High Affinity for a Panel of HIV-1 RT Variants

Elinder, M., Nordström, H. Geitmann, M., Hämäläinen, M., Vrang, L., Öberg, B. and Danielson, U.H.(2009)...

2009

Fragment library screening and lead characterization using SPR biosensors

Danielson, U.H. (2009) Curr. Top. Med. Chem. 9: 1725-1735

2009

Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process

Danielson, U.H. (2009) Future Med. Chem. 1(8): 1399-1414.

2009

Structural and functional analysis of hepatitis C virus strain JFH1 polymerase

Simister, P., Schmitt, M., Geitmann, M., Wicht, O., Danielson, U.H., Klein, R., Bressanelli, S. and Lohmann,...

2009

A protein interaction node at the neurotransmitter release site: Domains of Aczonin, Bassoon, CAST and Rim converge on the N-terminal domain of Munc13-1

Wang, X., Hu, B., Zieba, A., Neumann, N., Kasper-Sonnenberg, M., Honsbein, A., Hultqvist, G., Conze,...

2009

Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor

Christopeit, T., Gossas, T., and Danielson, U.H. (2009) Anal. Biochem., 391(1), 2009, 39-44.

2008

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

Nordström, H.; Gossas, T.; Hämäläinen, M.; Källblad, P.; Nyström, S.; Wallberg, H.; Danielson, U. H....

2007

Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis

Geitmann, M. and Danielson, U.H. (2007) Bioorg. Med. Chem. 15; 7344-54.

2007

Biomolecular Recognition of Glycosylated Peptides by GalNAc Specific Lectins

Norgren, A.S., Geitmann, M., Danielson, U.H., Arvidsson, P.I. (2007) J. Molecular Recognition 20: 132-138

2006

Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance

Geitmann, M., Unge, T. and Danielson, U.H. (2006) J. Med. Chem. 49(8): 2375 – 2387.

2006

Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors

Geitmann, M., Unge, T. and Danielson, U.H. (2006) J. Med. Chem. 49(8): 2375 – 2387.

2005

Early absorption and distribution analysis of anti-tumour and anti-AIDS drugs: Lipid membrane and plasma protein interactions

Cimitan, S., Lindgren, M., Bertucci, C. and Danielson, U.H. (2005) J. Medicinal Chemistry 48(10):3536-46.

2004

Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data

Shuman, C.F., Vrang, L. and Danielson, U.H. (2004) J. Medicinal Chemistry, 47(24):5953-61.

2004

Studies of substrate-induced conformational change in human cytomegalovirus protease using optical biosensor technology

Geitmann, M. and Danielson, U.H. (2004) Analytical Biochemistry, 332(2), 203-14.

2004

Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Poliakov, A., Johansson, A., Åkerblom, E., Oscarsson, K., Samuelsson, B., Hallberg, A., and Danielson,...

2004

Kinetic and thermodynamic characterization of HIV-1 protease inhibitors

Shuman, C F. Hämäläinen, M. Danielson, U H. (2004) J. Molecular Recognition, 17, 106-119.

2003

Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants

Shuman, C.F., Markgren, P.-O., Hämäläinen, M. and Danielson, U.H. (2003) Antiviral Research, 58, 235-242.

2003

Kinetic and mechanistic analysis of the association and dissociation of inhibitors interacting with secreted aspartic acid proteases 1 and 2 from Candida albicans

Backman, D. and Danielson, U.H. (2003) Biochimica et Biophysica Acta 1646, 184-195.

2003

Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors

Gossas, T. and Danielson, U.H. (2003) J.Mol. Recogn., 16, 203-212.

2002

Relationships between structure and interaction kinetics for HIV-1 protease inhibitors

Markgren, P.-O. , Schaal., W., Hämäläinen, M., Karlén, A., Hallberg, A., Samuelsson, B. and Danielson,...

2001

Capture and analysis of low molecular weight ligands by surface plasmon resonance combined with mass spectrometry

Sönksen, C.P., Markgren, P.-O., Hämäläinen, M., Jansson, Ö., Danielson, U.H. and Roepstorff, P. (2001)...

2001

Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology

Markgren, P.-O., Lindgren, M.T., Gertow, K., Karlsson, R., Hämäläinen, M.D. and Danielson, U.H. (2001)...

2001

Modified HIV protease inhibitors as tools in two new sensitive surface plasmon resonance biosensor screening assays

Alterman, M., Sjöbom, H., Säfsten, P., Markgren, P.-O., Danielson, U.H., Hämäläinen, M., Löfås, S., Hultén,...

2001

Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor based screen

Hämäläinen, M.D., Markgren, P.-O., Schaal, W., Karlén, A., Classon, B., Vrang, L. Samuelsson, B., Hallberg,...

2000

Kinetic analysis of the interaction between HIV-1 protease and inhibitors using optical biosensor technology

Markgren, P.-O., Hämäläinen, M. and Danielson, U.H. (2000) Analytical Biochemistry 279, 71-78.

1998

Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology

Markgren, P.-O., Hämäläinen, M. and Danielson, U.H. (1998) Analytical Biochemistry 265, 340-350.

Publications

Degraders of TEAD Transcription Factors Based on Interface 3 Binders

Multiplexed experimental strategies for fragment library screening against challenging drug targets using SPR biosensors

Potentiation of Immunotherapy by LSD1 Modulation

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor

Comparison of metabolic and mitogenic response in vitro of the rapid-acting insulin lispro product SAR342434, and US- and EU-approved Humalog®

LSD1 modulation by allosteric ligands

Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors

Development of (4-cyanophenyl)glycine derivatives as reversible inhibitors of lysine specific demethylase 1

Development and evaluation of 4-(pyrrolidin-3-yl)benzonitrile derivatives as inhibitors of lysine specific demethylase 1

Measuring the kinetic interaction of insulin analogs with solubilized full-length insulin receptors

Development of 5-hydroxypyrazole derivatives as reversible inhibitors of lysine specific demethylase 1

Biophysics in drug discovery: impact, challenges and opportunities

Identification and Characterization of an Irreversible Inhibitor of CDK2

Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the nicotinic acetylcholine receptor

Identification of Structural-Kinetic and Structural-Thermodynamic Relationships for Thrombin Inhibitors

The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors – characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors

Structural basis of ligand recognition in 5-HT3 receptors

Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker

Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function.

Histaminergic pharmacology of homo-oligomeric aminobutyric acid type A receptors characterized by surface plasmon resonance biosensor technology

Aliskiren displays long-lasting interactions with human renin

Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: implications for the charge state of the protein ionogenic groups.

AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein

Mechanistic and kinetic characterization of hepatitis C virus NS3 protein interactions with NS4A and protease inhibitors

Experimental Validation of a Fragment Library for Lead Discovery using SPR Biosensor Technology

Identification of a novel scaffold for allosteric inhibition of wild type and drug resistant HIV-1 Reverse transcriptase by fragment library screening

Quantification of interactions between drug leads and serum proteins by use of “binding efficiency”

Deconstruction of Non-Nucleoside Reverse Transcriptase Inhibitors of Human Immunodeficiency Virus Type 1 for Exploration of the Optimization Landscape of Fragments

A surface plasmon resonance based biosensor with full-length BACE1 in a reconstituted membrane.

Powerful protein binders from designed polypeptides and small organic molecules – a general concept for protein recognition.

Development of surface plasmon resonance biosensor assays for primary and secondary screening of AChBP ligands

Biotinylated lipid bilayer disks as model membranes for biosensor analyses

Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor Ligands

Effect of protonation state of the titrable residues on the inhibitor affinity to BACE1

Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism – Importance of slow dissociation and relaxation rates for antiviral efficacy

Screening for NNRTIs with Slow Dissociation and High Affinity for a Panel of HIV-1 RT Variants

Fragment library screening and lead characterization using SPR biosensors

Integrating surface plasmon resonance biosensor-based interaction kinetic analyses into the lead discovery and optimization process

Structural and functional analysis of hepatitis C virus strain JFH1 polymerase

A protein interaction node at the neurotransmitter release site: Domains of Aczonin, Bassoon, CAST and Rim converge on the N-terminal domain of Munc13-1

Characterization of Ca2+ and phosphocholine interactions with C-reactive protein using a surface plasmon resonance biosensor

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library

Additional level of information about complex interaction between non-nucleoside inhibitor and HIV-1 reverse transcriptase using biosensor-based thermodynamic analysis

Biomolecular Recognition of Glycosylated Peptides by GalNAc Specific Lectins

Interaction kinetic characterization of HIV-1 reverse transcriptase non-nucleoside inhibitor resistance

Biosensor-based kinetic characterization of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors

Early absorption and distribution analysis of anti-tumour and anti-AIDS drugs: Lipid membrane and plasma protein interactions

Improved structure-activity relationship analysis of HIV-1 protease inhibitors using interaction kinetic data

Studies of substrate-induced conformational change in human cytomegalovirus protease using optical biosensor technology

Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors

Kinetic and thermodynamic characterization of HIV-1 protease inhibitors

Elucidation of HIV-1 protease resistance by characterization of interaction kinetics between inhibitors and enzyme variants

Kinetic and mechanistic analysis of the association and dissociation of inhibitors interacting with secreted aspartic acid proteases 1 and 2 from Candida albicans

Analysis of the pH-dependencies of the association and dissociation kinetics of HIV-1 protease inhibitors

Relationships between structure and interaction kinetics for HIV-1 protease inhibitors

Capture and analysis of low molecular weight ligands by surface plasmon resonance combined with mass spectrometry

Determination of interaction kinetic constants for HIV-1 protease inhibitors using optical biosensor technology

Modified HIV protease inhibitors as tools in two new sensitive surface plasmon resonance biosensor screening assays

Characterization of a set of HIV-1 protease inhibitors using binding kinetics data from a biosensor based screen

Kinetic analysis of the interaction between HIV-1 protease and inhibitors using optical biosensor technology

Screening of compounds interacting with HIV-1 proteinase using optical biosensor technology

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